ParkinsonCanadaV1, Main, Exploration, bibRecord, 000251

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system.

Identifieur interne : 000251 ( Main/Exploration ); précédent : 000250; suivant : 000252

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system.

Auteurs : Katherine Coulombe [Canada] ; Martine Saint-Pierre [Canada] ; Giulia Cisbani [Canada] ; Isabelle St-Amour [Canada] ; Claire Gibrat [Canada] ; Ariane Giguère-Rancourt [Canada] ; Frédéric Calon [Canada] ; Francesca Cicchetti [Canada]

Source :

The Journal of nutritional biochemistry [ 1873-4847 ] ; 2016.

RBID : pubmed:27012630

English descriptors

KwdEn :
- Animals, Docosahexaenoic Acids (administration & dosage), Mice, Mice, Inbred C57BL, Motor Activity, Oxidopamine (administration & dosage).
MESH :
- chemical , administration & dosage : Docosahexaenoic Acids, Oxidopamine.
- Animals, Mice, Mice, Inbred C57BL, Motor Activity.

Abstract

Pre-clinical data collected in mouse models of Parkinson's disease (PD) support the neuroprotective potential of omega-3 polyunsaturated fatty acids (n-3 PUFA)-enriched diet on the dopaminergic (DAergic) system. In this study, we investigated the effects of an n-3 PUFA-rich diet using a neurorescue/neurorestorative paradigm. C57BL/6 adult mice were submitted to a striatal stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-OHDA) to induce striatal DAergic denervation and subsequent nigral DAergic cell loss. Three weeks post-lesion, mice received either a docosahexaenoic acid (DHA)-enriched or a control diet for a period of 6 weeks. HPLC analyses revealed a 111% post-lesion increase in striatal dopamine levels in the DHA-fed animals compared to controls (ctrl, P<0.05), although no improvement in the motor behavior was observed. DHA treatment led to a 89% rise in tyrosine-hydroxylase (TH)-immunoreactive terminals within the striatum (P<0.05) in lesioned animals. Despite the fact that DHA did not change the number of TH+ neurons in the substantia nigra pars compacta (SNpc), morphological analyses revealed an increased in perimeters (+7%) and areas (+21%) of DAergic cell bodies in treated animals. Collectively, our results suggest that DHA induces a partial neurorescue/neurorestoration of the DAergic system and support further studies to investigate the potential of a diet-based intervention, or at least the combination of such approach, to current treatments in PD.

DOI: 10.1016/j.jnutbio.2015.11.014
PubMed: 27012630

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Pre-clinical data collected in mouse models of Parkinson's disease (PD) support the neuroprotective potential of omega-3 polyunsaturated fatty acids (n-3 PUFA)-enriched diet on the dopaminergic (DAergic) system. In this study, we investigated the effects of an n-3 PUFA-rich diet using a neurorescue/neurorestorative paradigm. C57BL/6 adult mice were submitted to a striatal stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-OHDA) to induce striatal DAergic denervation and subsequent nigral DAergic cell loss. Three weeks post-lesion, mice received either a docosahexaenoic acid (DHA)-enriched or a control diet for a period of 6 weeks. HPLC analyses revealed a 111% post-lesion increase in striatal dopamine levels in the DHA-fed animals compared to controls (ctrl, P<0.05), although no improvement in the motor behavior was observed. DHA treatment led to a 89% rise in tyrosine-hydroxylase (TH)-immunoreactive terminals within the striatum (P<0.05) in lesioned animals. Despite the fact that DHA did not change the number of TH+ neurons in the substantia nigra pars compacta (SNpc), morphological analyses revealed an increased in perimeters (+7%) and areas (+21%) of DAergic cell bodies in treated animals. Collectively, our results suggest that DHA induces a partial neurorescue/neurorestoration of the DAergic system and support further studies to investigate the potential of a diet-based intervention, or at least the combination of such approach, to current treatments in PD.</div>
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       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

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Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system.

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system.

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Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.